All the data point to the fact that combining alcohol with sympathomimetics such as Vyvanse, Adderall, Ritalin or any kind of amphetamine is going to be more detrimental to the brain and body than simply taking those drugs on their own ... If you are taking any of the drugs that we've been talking about to treat ADHD, or if you just happen to be taking them for whatever reason, you are going to want to avoid drinking alcohol at any time.