There's a fairly extensive literature on the fact that fadogia agrestis can be toxic to testicular cells and perhaps other cells when taken at very high dosages. So, obeying the particular dosages of fadogia agrestis that are recommended on various product labels and cycling fadogia agrestis can be important. Some people need to cycle it 8 weeks on, 2 weeks off; other people opt for 12 weeks on, a month off.