People who drink regularly—so, this again could be just 1 or 2 drinks per night, or it could be somebody that drinks just on Fridays or just on Saturdays or maybe just on the weekend, 2-4 drinks—well, those people experience changes in their hypothalamic-pituitary-adrenal axis that result in more cortisol, more of this so-called stress hormone, being released at baseline when they are not drinking.